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Related Experiment Video

Updated: Mar 8, 2026

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
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A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

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Ischemia/Reperfusion.

Theodore Kalogeris1, Christopher P Baines1,2,3, Maike Krenz1,2

  • 1Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA.

Comprehensive Physiology
|January 31, 2017
PubMed
Summary
This summary is machine-generated.

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Ischemia and reperfusion (I/R) injury involves complex cellular events, including ATP depletion and calcium overload. Targeting multiple pathological processes is crucial for effective therapeutic strategies against I/R damage.

Area of Science:

  • Physiology
  • Pathology

Background:

  • Ischemic disorders like myocardial infarction and stroke are leading causes of death.
  • Tissue injury severity correlates with reduced blood flow and duration of ischemia, impacting cellular ATP and pH levels.

Purpose of the Study:

  • To review the multifaceted mechanisms contributing to ischemia/reperfusion (I/R) injury.
  • To highlight emerging concepts and therapeutic strategies for I/R-related conditions.

Main Methods:

  • Comprehensive review of existing literature on I/R injury mechanisms.
  • Discussion of cellular and molecular events, including ion transport, cell volume regulation, and oxidative stress.

Main Results:

  • Ischemia leads to ATP depletion, altered ion transport, and calcium overload.

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Last Updated: Mar 8, 2026

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
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Published on: April 10, 2014

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Model of Ischemia and Reperfusion Injury in Rabbits
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  • Reperfusion paradoxically exacerbates injury through reactive oxygen species, inflammation, and endoplasmic reticulum stress.
  • Mitochondrial permeability transition pore opening is a key event in I/R-induced cell death.

    • Conclusions:

    • I/R injury involves numerous interconnected pathological pathways.
    • Effective therapies must target multiple deleterious events.
    • Future research should utilize animal models reflecting cardiovascular disease risk factors for enhanced translational significance.