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Proanthocyanidins from Krameria triandra root.

E Scholz, H Rimpler

    Planta Medica
    |August 1, 1989
    PubMed
    Summary

    Oligomeric proanthocyanidins from rhatany root were identified, revealing a 65:35 ratio of propelagonidin to procyanidin. These compounds, particularly those with 5-10 flavanol units, are responsible for the astringency and exhibit antimicrobial properties.

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    Area of Science:

    • Phytochemistry
    • Natural Products Chemistry
    • Pharmacology

    Background:

    • Rhatany root (Krameria triandra) is traditionally used for its astringent properties.
    • Proanthocyanidins are a class of polyphenols known for their diverse biological activities.

    Purpose of the Study:

    • To isolate and characterize oligomeric proanthocyanidins from rhatany root.
    • To determine the chemical structures and linkages of these compounds.
    • To investigate the source of the drug's astringency and its pharmacological effects.

    Main Methods:

    • Isolation of oligomeric proanthocyanidins from Krameria triandra.
    • Characterization using acid hydrolysis, thiolytic degradation, and spectroscopic techniques.
    • Pharmacological screening for antimicrobial activity.

    Main Results:

    • Oligomeric proanthocyanidins comprised 2-14 flavanol units with a 2,3-cis configuration.
    • The propelagonidin:procyanidin ratio was 65:35, with a predominant [4,8] interflavan linkage.
    • Higher oligomers contained [4,6]-bonds, suggesting branched structures.
    • Astringency was primarily attributed to proanthocyanidins with degrees of polymerization from 5-10.
    • Significant antimicrobial effects were observed in the rhatany extract.

    Conclusions:

    • The study elucidated the complex structure of oligomeric proanthocyanidins in rhatany root.
    • These proanthocyanidins are key contributors to the astringency of rhatany preparations.
    • Rhatany root extract possesses notable antimicrobial activity, warranting further investigation.

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