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miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma
Guan Sun1,2, Ying Cao2, Peibei Wang3
1a Department of Neurosurgery , The Forth Affiliated Hospital of Nantong Medical College , Yancheng , Jiangsu , China.
Context:
Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour.
Objective:
Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC).
Materials And Methods:
miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls.
Results:
Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis.
Discussion And Conclusion:
Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.
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