Related Experiment Video
Updated: Mar 8, 2026
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
The Relationship between Pulse Wave Velocity and Coronary Artery Stenosis and Percutaneous Coronary Intervention: a
Hyung Joon Joo1, Sang-A Cho1, Jae-Young Cho1
1Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, 126-1, 5ka, Anam-dong, Sungbuk-ku, Seoul, 136-705, Republic of Korea.
Insights
Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), predicts coronary artery stenosis (CAS) in patients without prior intervention. However, this predictive value is lost in patients with a history of percutaneous coronary intervention (PCI).
Area of Science:
- Cardiovascular Medicine
- Diagnostic Imaging
- Biomedical Engineering
Background:
- Arterial stiffness is a potential predictor of coronary artery stenosis (CAS).
- Limited data exist on aortic stiffness and CAS in patients post-percutaneous coronary intervention (PCI).
- Investigating arterial stiffness and CAS in patients with and without PCI history is crucial.
Purpose of the Study:
- To examine the association between arterial stiffness and CAS in patients with and without a history of PCI.
- To determine if brachial-ankle pulse wave velocity (baPWV) can predict CAS in these patient groups.
Main Methods:
- Retrospective study of 1093 patients undergoing coronary angiography (CAG).
- Arterial stiffness assessed using brachial-ankle pulse wave velocity (baPWV) before CAG.
- Multivariate logistic regression analysis to identify risk predictors.
Main Results:
- In patients without PCI history, higher baPWV correlated with CAS (p < 0.001).
- No significant baPWV difference was observed in patients with PCI history.
- baPWV independently predicted CAS in non-PCI patients, but not in PCI patients (OR 1.106, p=0.002).
Conclusions:
- The predictive capability of baPWV for CAS is significantly reduced in patients with a history of PCI.
- Arterial stiffness assessment may require different interpretation in post-PCI patients.
Background:
Arterial stiffness has been suggested as a valuable predictor of coronary artery stenosis (CAS). However, little data are available on aortic stiffness and CAS in patients who have previously undergone percutaneous coronary artery intervention (PCI). The aim of this study was to investigate the association of arterial stiffness to CAS in patients with a history of PCI and those without a history of PCI.
Methods:
We retrospectively studied 1093 consecutive patients who had undergone coronary angiography (CAG). Arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV) measured prior to CAG.
Results:
In patients without a history of PCI, baPWV significantly increased in patients with CAS compared to that in patients without CAS (p < 0.001). However, among patients with a history of PCI, there was no significant difference in baPWV. Multivariate logistic regression analysis demonstrated that baPWV was an independent risk predictor for CAS in patients without a history of PCI, but not in those with a history of PCI (OR 1.106, 95% CI 1.039-1.177, p = 0.002). In CAS patients without a history of PCI, increased baPWV was significantly associated with multiple cardiovascular risk factors, multivessel involvement, and anatomical severity.
Conclusions:
Prediction of CAS by baPWV is significantly attenuated in patients with a history of PCI.
