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Updated: Mar 8, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
Published on: October 10, 2011
The evolving concept of liver cancer stem cells
Kouki Nio1,2, Taro Yamashita3, Shuichi Kaneko2
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Marsico Hall 5229 M, 125 Mason Farm Rd, 27599, Chapel Hill, NC, USA.
Abstract:
Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment.
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