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Updated: Mar 8, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
Published on: May 7, 2013
Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection
Alexander L Chernorudskiy1, Ester Zito1
1Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy.
Abstract:
Calcium signaling plays an important role in cell survival by influencing mitochondria-related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca2+; ~60-500μM), and the Ca2+ released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca2+ signaling that is mediated by Ca2+-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca2+ signals from the ER to mitochondria.
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