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Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning
Guang-Zhi Yang1, Jiao-Jiao Li1, Deng-Guang Yu1
1School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Acta Biomaterialia
|February 1, 2017
Summary
Researchers developed novel nanoscale drug depots using cellulose acetate (CA) and ferulic acid (FA) via modified tri-axial electrospinning. These core-shell fibers offer sustained drug release, avoiding initial burst effects for improved pharmaceutical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Nanoscale drug depots are crucial for advanced pharmaceutical research.
- Developing controlled drug release systems remains a significant challenge.
Purpose of the Study:
- To design and fabricate nanoscale drug depots with a core-shell structure.
- To evaluate the drug release profile of these novel depots.
- To compare the performance against traditional monolithic fibers.
Main Methods:
- Utilized cellulose acetate (CA) as the carrier and ferulic acid (FA) as the model drug.
- Employed a modified tri-axial electrospinning process with a solvent mixture.
- Characterized the core-shell fibers using electron microscopy, X-ray diffraction, and IR spectroscopy.
- Conducted in vitro dissolution tests to assess drug release kinetics.
Main Results:
- Successfully fabricated core-shell fibers with an average diameter of 0.62±0.07μm.
- Confirmed the encapsulation of FA within the CA shell, with FA in crystalline form.
- Demonstrated near zero-order drug release over 36 hours with no initial burst release.
- Observed significantly improved release properties compared to monolithic CA/FA fibers.
Conclusions:
- Modified tri-axial electrospinning is effective for creating heterogeneous nanoscale biomaterials.
- The developed core-shell fiber depots offer superior sustained drug release profiles.
- This approach provides a foundation for new biomaterials with enhanced functional performance.
