Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.5K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.2K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.2K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.2K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

432
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
432
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

14.4K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
14.4K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

600
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
600

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous Pyruvate Supplementation Enhances Neuroprotective Resilience Against Kainate-Induced Status Epilepticus Through Metabolic Preconditioning.

Biomolecules·2026
Same author

Development of the Korean Version of the Children's Palliative Care Outcome Scale.

Journal of pain and symptom management·2026
Same author

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study).

Diabetes, obesity & metabolism·2026
Same author

Multi-Omics-Based Biological Mechanisms for Childhood Allergen Sensitization Trajectories: COCOA Study.

Allergy·2026
Same author

Central Adiposity, Obesity, Metabolic Syndrome, and the Risk of Thyroid Cancer in Adults Aged ≥75 Years: A Nationwide Korean Cohort Study.

Cancers·2026

Related Experiment Video

Updated: Mar 8, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K

Contact system activation and high thrombin generation in hyperthyroidism.

Namhee Kim1, Ja-Yoon Gu1, Hyun Ju Yoo1

  • 1Department of Laboratory Medicine and Cancer Research InstituteSeoul National University College of Medicine, Seoul, Korea.

European Journal of Endocrinology
|February 1, 2017
PubMed
Summary
This summary is machine-generated.

Hyperthyroidism activates the contact system and neutrophil extracellular trap (NET) formation, increasing thrombotic risk. These markers correlate with disease severity and free T4 levels.

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 8, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K

Area of Science:

  • Hematology
  • Endocrinology
  • Thrombosis Research

Background:

  • Hyperthyroidism is linked to a higher risk of blood clots (thrombosis).
  • Neutrophil extracellular traps (NETs) are increasingly recognized as a key factor in triggering thrombosis.
  • This study investigates the activation of the contact system and NET formation in hyperthyroidism.

Purpose of the Study:

  • To determine if the contact system is activated in hyperthyroidism.
  • To assess the extent of NET formation in hyperthyroid patients.
  • To correlate markers of contact system activation, NET formation, and thrombin generation with hyperthyroidism severity.

Main Methods:

  • Measured coagulation factors, D-dimer, and thrombin generation assay (TGA) markers in 61 hyperthyroid patients and 40 controls.
  • Assessed NET formation markers (histone-DNA complex, double-stranded DNA, neutrophil elastase) and contact system markers (factor XIIa, HMWK, prekallikrein, bradykinin).
  • Utilized logistic regression analysis to evaluate the association between markers and hyperthyroidism.

Main Results:

  • Hyperthyroid patients exhibited significantly higher levels of fibrinogen, D-dimer, peak thrombin, neutrophil elastase, factor XIIa, HMWK, and bradykinin compared to controls.
  • Logistic regression revealed significant odds ratios for fibrinogen, factor VIII, IX, XIIa, D-dimer, peak thrombin, neutrophil elastase, HMWK, and bradykinin, indicating their contribution to hyperthyroidism-related coagulation and contact system activation.
  • Free T4 levels positively correlated with factors VIII and IX, D-dimer, double-stranded DNA, and bradykinin.

Conclusions:

  • Hyperthyroidism is characterized by activated contact system and significant NET formation.
  • These activations contribute to a hypercoagulable state with elevated thrombin generation.
  • The observed markers correlate with disease severity, specifically free T4 levels.