Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

25.6K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
25.6K
What is Cell Signaling?02:03

What is Cell Signaling?

131.9K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.9K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

8.2K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.2K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

54.2K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
54.2K
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

262
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
262
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

7.6K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oscillation quenching induced by time-varying coupling functions.

Chaos (Woodbury, N.Y.)Ā·2025
Same author

Recent achievements in nonlinear dynamics, synchronization, and networks.

Chaos (Woodbury, N.Y.)Ā·2024
Same author

Non-asymptotic transients away from steady states determine cellular responsiveness to dynamic spatial-temporal signals.

PLoS computational biologyĀ·2023
Same author

The EGFR phosphatase RPTPĪ³ is a redox-regulated suppressor of promigratory signaling.

The EMBO journalĀ·2023
Same author

Cells use molecular working memory to navigate in changing chemoattractant fields.

eLifeĀ·2022
Same author

Ultrarapid cryo-arrest of living cells on a microscope enables multiscale imaging of out-of-equilibrium molecular patterns.

Science advancesĀ·2021

Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

Cell signaling as a cognitive process.

Aneta Koseska1, Philippe Ih Bastiaens1,2

  • 1Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany aneta.koseska@mpi-dortmund.mpg.de philippe.bastiaens@mpi-dortmund.mpg.de.

The EMBO Journal
|February 1, 2017
PubMed
Summary

Cellular identity arises from dynamic intracellular networks, not just genes. Intercellular communication creates unique cellular behaviors, influencing cell differentiation and diseases like cancer.

Keywords:
cellular fateintercellular communicationnetwork reconstructionnetwork topologyprotein network dynamics

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

6.5K
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.9K

Related Experiment Videos

Last Updated: Mar 8, 2026

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K
The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

6.5K
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.9K

Area of Science:

  • Cellular and Molecular Biology
  • Systems Biology
  • Biochemistry

Background:

  • Cellular identity, defined by morphology and function, originates from intracellular signaling networks.
  • Interactions within and between these networks generate complex biochemical behaviors.
  • Cellular heterogeneity in tissues suggests identity is dynamically maintained, not solely gene-determined.

Purpose of the Study:

  • To explore how intracellular biochemical networks generate context-dependent cellular behavior.
  • To experimentally measure information flow within these networks.
  • To apply these concepts to understand cell differentiation and tumorigenesis.

Main Methods:

  • Analysis of recursive interactions within intracellular signaling networks.
  • Experimental measurement of information flow in biochemical networks.
  • Modeling of intercellular communication effects on cellular dynamics.

Main Results:

  • Simple causality motifs in networks yield rich, context-dependent dynamic behaviors.
  • Intercellular communication leads to novel dynamical solutions compared to isolated cells.
  • Cellular heterogeneity is established through these dynamic network interactions.

Conclusions:

  • Cellular identity is dynamically maintained through a cognitive process involving intracellular and intercellular communication.
  • Understanding network dynamics is crucial for contextualizing cell differentiation and tumorigenesis.
  • Experimental measurement of information flow provides insights into cellular decision-making.