Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.7K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

716
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
716
Wald-Wolfowitz Runs Test II01:17

Wald-Wolfowitz Runs Test II

604
The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure.
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and 0s. In...
604
Wald-Wolfowitz Runs Test I01:17

Wald-Wolfowitz Runs Test I

1.0K
The Wald-Wolfowitz test, also known as the runs test, is a nonparametric statistical test used to assess the randomness of a sequence of two different types of elements (e.g., positive/negative values, successes/failures). It examines whether the order of the elements in a sequence is random or if there is a pattern or trend present. This nonparametric test applies to any ordered data despite the population and sample data distribution, even if a higher sample size is available.
The test works...
1.0K
Sex-linked Disorders01:43

Sex-linked Disorders

110.0K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
110.0K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental health short stay units in Australia: a scoping review.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

Contributors to seclusion use in adult mental health inpatient units across organization for economic cooperation and development countries: A systematic literature review.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

Should we expect the same mental health promotion campaigns to work in all settings? An argumentative review.

Global health promotion·2026
Same author

Quetiapine Extended-Release and Peripheral Edema: A Case Report and Literature Review.

Case reports in psychiatry·2025
Same author

A randomised controlled trial to compare the efficacy, safety, and tolerability of low dose, short course primaquine in adults with uncomplicated P. vivax malaria in two hospitals in India.

Trials·2024
Same author

A Brief on Cultural Relativity: Framework Shifts and Delusions.

Indian journal of psychological medicine·2023

Related Experiment Video

Updated: Mar 8, 2026

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
07:18

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

6.4K

Mania in Wolfram's Disease: From Bedside to Bench.

Seshadri Sekhar Chatterjee1, Sayantanava Mitra2, Salil Kumar Pal3

  • 1Department of Psychiatry, Medical College, Calcutta National Medical College, Kolkata, India.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|February 1, 2017
PubMed
Summary

Wolfram syndrome, a rare genetic disorder, is linked to psychiatric conditions like psychosis and manic episodes. Understanding the WFS1 gene

Keywords:
Bipolar DisorderComorbidityWolfram syndrome

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
07:18

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

6.4K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Wolfram syndrome (WS) is a rare, autosomal recessive neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.
  • While WS is primarily known for its systemic manifestations, its association with psychiatric disorders remains an under-explored area in clinical psychiatry.
  • The discovery of the WFS1 gene, implicated in WS, initially sparked interest in its role in psychiatric conditions.

Observation:

  • This report details a case of Wolfram syndrome presenting with recurrent manic episodes, highlighting a significant psychiatric manifestation.
  • The patient experienced multiple manic episodes, suggesting a potential link between WS and affective disorders.

Findings:

  • The case underscores the importance of considering Wolfram syndrome in patients with unexplained psychiatric symptoms, particularly affective disturbances.
  • Genetic underpinnings of the WFS1 gene may contribute to the observed psychiatric symptoms, including manic episodes.

Implications:

  • Further research into the neurobiological mechanisms connecting Wolfram syndrome and psychiatric illnesses is warranted.
  • Recognizing the psychiatric manifestations of WS is crucial for comprehensive patient management and improving diagnostic approaches.
  • This case highlights the need for integrated care addressing both the systemic and psychiatric aspects of Wolfram syndrome.