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Published on: December 4, 2023
Decrease of RBM4 indicates poor prognosis in patients with hepatocellular carcinoma after hepatectomy
Jian-Yao Chen1, Li-Ping Liu2, Jiang-Feng Xu3
1Department of Hepatobiliary Surgery, Shaoxing Second Hospital, Shaoxing.
Abstract:
RNA-binding motif 4 (RBM4) has been reported to play an important role in many human tumors such as lung cancer, breast cancer, ovarian cancer and gastric cancer by regulating alternative splicing and messenger RNA (mRNA) translation. However, little is known about the role of RBM4 in the development of hepatocellular carcinoma (HCC). This study aimed to investigate the expression of RBM4 in HCC tissues. Expression of RBM4 was detected by immunohistochemistry in 95 cases of HCC. Correlations of RBM4 expression with the overall survival and disease-free survival of HCC were also studied. Patients with high RBM4 expression had better overall survival rate and disease-free survival rate than those with low RBM4 expression (P<0.001, P=0.007, respectively). RBM4 expression, together with tumor numbers, capsular formation, vascular invasion and Barcelona clinic liver cancer (BCLC) stage, was an independent prognostic factor for overall survival rate and disease-free survival rate of HCC. Our data implicate RBM4 as a novel prognostic marker and a potential therapeutic target for HCC.
Insights
High expression of RNA-binding motif 4 (RBM4) correlates with better survival rates in hepatocellular carcinoma (HCC) patients. RBM4 may serve as a novel prognostic marker and therapeutic target for HCC.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- RNA-binding motif 4 (RBM4) is implicated in various human cancers, influencing alternative splicing and mRNA translation.
- The role of RBM4 in hepatocellular carcinoma (HCC) development remains largely unexplored.
Purpose of the Study:
- To investigate the expression levels of RBM4 in HCC tissues.
- To evaluate the prognostic significance of RBM4 expression in HCC patients.
Main Methods:
- Immunohistochemistry was employed to detect RBM4 expression in 95 HCC tissue samples.
- Statistical analyses were performed to correlate RBM4 expression with overall survival and disease-free survival.
Main Results:
- Higher RBM4 expression was significantly associated with improved overall survival and disease-free survival rates in HCC patients (P<0.001 and P=0.007, respectively).
- RBM4 expression emerged as an independent prognostic factor for HCC, alongside tumor number, capsular formation, vascular invasion, and BCLC stage.
Conclusions:
- RBM4 expression is a significant prognostic indicator in HCC.
- RBM4 represents a potential therapeutic target for hepatocellular carcinoma.
