Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Siderophore production by the lichen fungus Xanthoria parietina supports its algal symbiont.

Nature communications·2026
Same author

Driving clinical excellence through a management driven framework for integrating nuclear medicine into hospital ecosystems.

Frontiers in nuclear medicine·2026
Same author

Side-by-Side Comparison of Different Thiol Bioconjugation Strategies for the Chemoselective Radiolabeling of Human Serum Albumin with Zirconium-89.

ACS bio & med chem Au·2026
Same author

Bismuth meets siderophores: Thermodynamic insights into Bi(III) complexes with Desferrioxamine B and E.

Journal of inorganic biochemistry·2026
Same author

Investigation of Radiolabeled KISS1R Ligands as Promising Tools for Diagnosis and Treatment of Triple-Negative Breast Cancer.

Molecular pharmaceutics·2026
Same author

Functional-based forensic surveillance: Leveraging PET and PET/MR imaging for the strategic screening of new psychoactive substances.

Forensic science, medicine, and pathology·2026

Related Experiment Video

Updated: Mar 8, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

6.2K

Siderophores for molecular imaging applications.

Milos Petrik1, Chuangyan Zhai2, Hubertus Haas3

  • 10000 0001 1245 3953grid.10979.36Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic.

Clinical and Translational Imaging
|February 1, 2017
PubMed
Summary

Siderophores, iron-scavenging molecules, are revolutionizing molecular imaging, especially for infection detection using radionuclides like Gallium-68. Their potential extends to optical imaging and theranostics, offering new avenues for clinical applications.

Keywords:
Bifunctional chelatorDesferrioxamineInfectionSiderophoresTriacetylfusarinine C

More Related Videos

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
05:05

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle

Published on: November 4, 2011

21.8K
Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control
05:09

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Published on: March 15, 2024

6.3K

Related Experiment Videos

Last Updated: Mar 8, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

6.2K
Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
05:05

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle

Published on: November 4, 2011

21.8K
Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control
05:09

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Published on: March 15, 2024

6.3K

Area of Science:

  • Biochemistry
  • Radiochemistry
  • Medical Imaging

Background:

  • Siderophores are low molecular weight iron chelators produced by microbes.
  • Desferrioxamine (DFO) is a well-established siderophore used for iron overload diseases.
  • Siderophore systems are upregulated during infections, making them targets for imaging.

Purpose of the Study:

  • To review publications on siderophore applications in molecular imaging, focusing on radionuclide-based techniques.
  • To explore the potential of siderophores in targeted infection imaging and theranostics.
  • To highlight recent advancements in siderophore-based chelators for Positron Emission Tomography (PET).

Main Methods:

  • Review of scientific literature on siderophores and molecular imaging.
  • Analysis of radionuclide incorporation into siderophores for imaging applications.
  • Evaluation of bifunctional chelators based on siderophore structures for PET imaging.

Main Results:

  • Siderophores, particularly DFO, are effective bifunctional chelators for radionuclides like Gallium-68 (Ga-68) and Zirconium-89 (Zr-89).
  • 68Ga-labeled siderophores show promise for targeted imaging of infections, with proof of principle for fungal infections.
  • Novel DFO constructs and cyclic siderophore-based chelators demonstrate potential for radiopharmaceutical development in PET.

Conclusions:

  • Siderophores offer significant potential for advancing molecular imaging, particularly for infection detection and theranostics.
  • Further research and clinical translation of siderophore-based imaging agents are warranted.
  • Siderophores are becoming standard chelators in advanced imaging techniques like Immuno-PET.