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Corneal profile in primary congenital glaucoma
Azadeh Doozandeh1, Shahin Yazdani1,2, Shabnam Ansari1
1Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Acta Ophthalmologica
|February 1, 2017
Summary
Primary congenital glaucoma (PCG) alters corneal biomechanics and ultrastructure, even with clear corneas. These changes impact ocular biometrics and require consideration for surgical planning in PCG patients.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Corneal Science
Background:
- Primary congenital glaucoma (PCG) is a rare but severe form of glaucoma.
- Understanding the ocular and corneal changes in PCG is crucial for management.
Purpose of the Study:
- To investigate biomechanical and ultrastructural corneal parameters and ocular biometrics in unilateral PCG.
- Compare affected eyes to unaffected fellow eyes and healthy controls.
Main Methods:
- Evaluated 12 patients with treated unilateral PCG and 10 healthy controls.
- Used LENSTAR for biometrics, Ocular Response Analyzer for biomechanics, and confocal microscopy for ultrastructure.
Main Results:
- Affected eyes showed increased axial length, flatter keratometry, and deeper anterior chambers.
- Corneal hysteresis was significantly reduced; endothelial cell density was also lower.
- No significant difference in central corneal thickness was observed.
Conclusions:
- Corneal biometrics, biomechanics, and ultrastructure are altered in PCG eyes, irrespective of corneal clarity.
- These findings are important for preoperative assessments in patients undergoing ocular or corneal surgery.
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