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Updated: Mar 8, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
MicroRNA 155 and viral-induced neuroinflammation
Laura L Dickey1, Timothy M Hanley1, Thomas B Huffaker1
1Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, United States.
Abstract:
MicroRNA (miRNA) regulation of gene expression is becoming an increasingly recognized mechanism by which host immune responses are governed following microbial infection. miRNAs are short, non-coding RNAs that repress translation of target genes, and have been implicated in a number of activities that modulate host immune responses, including the regulation of immune cell proliferation, survival, expansion, differentiation, migration, polarization, and effector function. This review highlights several examples in which mammalian-encoded miR-155 influences immune responses following viral infection of the CNS.
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