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Related Experiment Video

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Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen.

Lasse Malmqvist1, Luis de Santiago2, Luciano Boquete2

  • 1Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.

Acta Ophthalmologica
|February 1, 2017
PubMed
Summary
This summary is machine-generated.

Multifocal visual evoked potential (mfVEP) amplitude is reduced in optic disc drusen (ODD) patients, indicating optic nerve dysfunction. This research supports mfVEP

Keywords:
mfVEPmultifocal visual evoked potentialsoptic disc drusenoptic nerve dysfunction

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Optic disc drusen (ODD) are calcified deposits within the optic nerve head.
  • The impact of ODD on optic nerve function is not fully understood.
  • Multifocal visual evoked potentials (mfVEPs) measure the visual pathway's electrical activity.

Purpose of the Study:

  • To evaluate the utility of mfVEPs for ODD research and clinical diagnosis.
  • To assess mfVEP amplitude and latency in patients with ODD for the first time.

Main Methods:

  • mfVEP amplitude and latency were recorded in 33 ODD patients and 22 controls.
  • Signal-to-noise ratio (SNR) and peak-to-peak analysis were used for amplitude.
  • Second peak and cross-correlation analyses were employed for latency measurements.

Main Results:

  • ODD patients exhibited significantly decreased mean overall, inner ring, and outer ring mfVEP amplitudes (p < 0.001).
  • A 7 ms delay in monocular latency was observed in ODD patients (p = 0.001).
  • mfVEP amplitude correlated significantly with automated perimetric mean deviation and retinal nerve fiber layer thickness.

Conclusions:

  • Reduced mfVEP amplitude in ODD patients suggests mechanical compression of optic nerve axons.
  • mfVEP amplitude is a viable tool for assessing optic nerve dysfunction in ODD.