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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Meiosis II01:57

Meiosis II

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Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
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Birth Control Methods01:22

Birth Control Methods

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Fertilization01:38

Fertilization

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
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Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

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Use of Intracytoplasmic Sperm Injection and Birth Outcomes in Women Conceiving through In Vitro Fertilization.

Xu Xiong1, Richard P Dickey2, Pierre Buekens1

  • 1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.

Paediatric and Perinatal Epidemiology
|February 1, 2017
PubMed
Summary

Intracytoplasmic sperm injection (ICSI) use increased, but pregnancies had higher birth defect risks compared to conventional in vitro fertilization (IVF). ICSI may be overused, especially in couples without male factor infertility.

Keywords:
birth defectsin vitro fertilizationinfertilityintracytoplasmic sperm injectionpregnancy

More Related Videos

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
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OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

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Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
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Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

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Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
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Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

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Area of Science:

  • Reproductive medicine andrology
  • Obstetrics and gynecology
  • Perinatal health

Background:

  • Intracytoplasmic sperm injection (ICSI) use has risen despite limited evidence of superiority over conventional in vitro fertilization (IVF).
  • This trend is notable among couples without male factor infertility.

Purpose of the Study:

  • To assess the frequency of ICSI use in IVF procedures.
  • To evaluate the impact of ICSI on various birth outcomes.

Main Methods:

  • Retrospective cohort study utilizing data from 141,030 women undergoing IVF between 2006 and 2010.
  • Data sourced from the Society for Assisted Reproductive Technology (SART) registry.

Main Results:

  • ICSI use increased from 68.9% to 73.1% overall between 2006-2010, with a significant rise in women without male factor infertility.
  • No significant differences in multiple pregnancy, preterm delivery, stillbirth, or neonatal death rates were found between ICSI and conventional IVF.
  • ICSI-conceived pregnancies showed a higher risk of birth defects (3.0% vs. 2.5%) compared to conventional IVF, regardless of male factor infertility status.

Conclusions:

  • Higher birth defect rates are associated with ICSI conception.
  • Given that about half of ICSI procedures are performed on couples without male factor infertility, its use may be excessive in current practice.