Related Experiment Video

Updated: Mar 8, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

41.0K

Acute-Phase Proteins and Iron Status in Cats with Chronic Kidney Disease

R Javard1, C Grimes2, L Bau-Gaudreault2

  • 1Companion Animal Research Group, Department of Clinical Sciences, University of Montreal, Saint-Hyacinthe, QC, Canada.

Journal of Veterinary Internal Medicine
|February 1, 2017
PubMed

Insights

Inflammation and altered iron metabolism are linked to chronic kidney disease (CKD) in cats. Elevated hepcidin and serum amyloid A (SAA) indicate these changes, potentially contributing to anemia in feline CKD.

Area of Science:

  • Veterinary Medicine
  • Nephrology
  • Immunology

Background:

  • The role of inflammation in feline chronic kidney disease (CKD) is not well understood.
  • Hepcidin, an acute-phase protein (APP), impacts iron metabolism and anemia in human CKD.
  • This study investigates inflammation and iron status in cats with CKD.

Purpose of the Study:

  • To compare serum APP concentrations, iron status, and erythropoietin (EPO) in healthy cats versus cats with naturally occurring CKD.
  • To explore the relationship between inflammation markers and iron metabolism in feline CKD.

Main Methods:

  • A prospective study involving 18 healthy cats and 38 cats with CKD.
  • Measured serum amyloid A (SAA), haptoglobin (HAP), EPO, iron, ferritin, and total iron-binding capacity (TIBC).
  • Quantified serum hepcidin-25 using an ELISA kit.

Main Results:

  • Cats with CKD showed significantly higher SAA and hepcidin, and lower iron and TIBC.
  • Elevated SAA and hepcidin correlated with decreased TIBC and hematocrit in CKD cats.
  • Anemia (37% of CKD cats) was associated with lower TIBC, suggesting functional iron deficiency.

Conclusions:

  • Feline CKD is associated with systemic inflammation and disturbed iron metabolism.
  • Hepcidin and SAA may serve as indicators of inflammation in feline CKD.
  • Further validation of hepcidin assays could enhance understanding of these relationships in cats.
Abstract

Keywords:
anemiaerythropoietinferritinhepcidinserum amyloid A

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

5.0K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
559
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
420
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.1K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.5K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
842
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.0K