[The cutaneous bioavailability of alpha-chymotrypsin from ointments]

In view of improving the cutaneous bioavailability of alpha-chymotrypsin from ointments, the stability of this enzyme in two hydrophile ointment bases, macrogoli and carbopol, was tested. The cutaneous bioavailability of alpha-chymotrypsin in ointments, estimated by determining the anti-inflammatory action, underlines the important role played both by the ointment base and by the enzyme activating substances. By correlating the determinations of alpha-chymotrypsin enzymatic activity with the anti-inflammatory action a correlation between the manifested activity and the active substance stability was noticed.