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Published on: November 20, 2015
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Risk factors for brain damage among preterm twins
Irit Schushan-Eisen1, Ayala Maayan-Metzger1, Ram Mazkereth1
1a Department of Neonatology , The Edmond and Lily Safra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
Summary
This study found no specific risk factors for brain pathologies in preterm twins. However, severe brain injuries were more common in the larger twin, suggesting potential growth-related conflicts.
Area of Science:
- Neonatal neurology
- Perinatal medicine
- Twin studies
Background:
- Preterm twins face unique risks for brain pathologies.
- Understanding risk factors is crucial for early intervention and improved outcomes.
Purpose of the Study:
- To investigate perinatal and postnatal risk factors for brain pathologies in preterm twins.
- To compare brain injury incidence between co-twins.
Main Methods:
- Retrospective analysis of 104 twin pairs with discordant head ultrasound (HUS) findings.
- Matched control design comparing affected infants with their healthy co-twins.
Main Results:
- Common pathologies included periventricular echodensities, intraventricular hemorrhage, and cystic periventricular leukomalacia.
- No significant differences in perinatal/postnatal complications between study and control co-twins.
- Severe brain pathologies were more frequent in the larger twin sibling.
Conclusions:
- Specific risk factors for brain pathologies in preterm twins could not be identified.
- The increased incidence of severe brain injury in larger co-twins warrants further investigation.
- Future research should focus on the clinical implications and potential conflicts in discordant twin pairs.
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