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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
Published on: October 2, 2020
Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells
Mehreen Ahmed1, Kritika Chaudhari2, Roya Babaei-Jadidi1,3
1Cancer Genetics & Stem Cell Group, Nottingham, United Kingdom.
None:
Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem-like cell properties and which may be responsible for overall tumor maintenance. These cancer stem-like cells (CSCs) appear to have unique tumor-initiating ability and innate survival mechanisms that allow them to resist cancer therapies, consequently promoting relapses. Selective targeting of CSCs may provide therapeutic benefit and several recent reports have indicated this may be possible. In this article, we review drugs targeting CSCs, in selected epithelial cell-derived cancers. Stem Cells 2017;35:839-850.
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