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Related Concept Videos

Biological Causes of Schizophrenia01:29

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Brain structural and functional dissociated patterns in schizophrenia.

Chuanjun Zhuo1,2,3,4, Jiajia Zhu5, Chunli Wang6

  • 1Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China. chuanjunzhuotjmh@163.com.

BMC Psychiatry
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Summary

Schizophrenia alters brain structure and function. Gray matter volume (GMV) and global functional connectivity density (gFCD) changes occurred in different brain regions, suggesting independent contributions to the disorder.

Keywords:
Functional connectivityGray matter volumeSchizophreniaSpatial distributionStructural brain alterations

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Schizophrenia is characterized by gray matter volume (GMV) and global functional connectivity density (gFCD) aberrations.
  • Previous research has not explored the spatial distribution patterns of these GMV and gFCD alterations together.

Purpose of the Study:

  • To investigate pattern changes in gFCD and GMV in schizophrenia patients.
  • To analyze the associated spatial distributions of these alterations.

Main Methods:

  • Structural and resting-state functional MRI scans were acquired from 95 schizophrenia patients and 93 healthy controls.
  • Global functional connectivity density (gFCD) and gray matter volume (GMV) were assessed.

Main Results:

  • Schizophrenia patients showed increased gFCD in subcortical and limbic regions, and decreased gFCD in cortical regions.
  • Decreased GMV was observed in frontal, parietal, temporal, occipital, cingulate cortices, insular, striatum, and thalamus.
  • No significant correlations were found between GMV and gFCD changes or their spatial patterns.

Conclusions:

  • Both gFCD and GMV are perturbed in schizophrenia, with consistent decreases in cortical regions.
  • Subcortical regions exhibited opposite patterns: increased gFCD and decreased GMV.
  • Structural and functional alterations appear to independently contribute to schizophrenia neurobiology.