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O-GlcNAc transferase regulates excitatory synapse maturity.

Olof Lagerlöf1,2, Gerald W Hart2, Richard L Huganir3

  • 1Solomon H. Snyder Department of Neuroscience and Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Proceedings of the National Academy of Sciences of the United States of America
|February 2, 2017
PubMed
Summary

O-GlcNAc transferase (OGT) regulates synapse maturity. Postsynaptic OGT knockout reduces AMPA receptor subunits and dendritic spine development, impacting neuronal circuits and adaptive behavior.

Keywords:
AMPA receptorsO-GlcNAcOGTexcitatory synapses

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