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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
Published on: May 24, 2017
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RNA modifications and structures cooperate to guide RNA-protein interactions.
Cole J T Lewis1, Tao Pan2, Auinash Kalsotra1,3
1Department of Biochemistry, University of Illinois.
Nature Reviews. Molecular Cell Biology
|February 2, 2017
Summary
RNA modifications and structures control gene expression by influencing RNA-protein interactions. This interplay dynamically regulates the transcriptome, impacting crucial cellular functions.
Area of Science:
- Molecular Biology
- Gene Regulation
- Biochemistry
Background:
- Post-transcriptional gene regulation involves mRNA sequence, structure, and base modifications.
- These elements are dynamic, interdependent, and control the transcriptome.
- RNA features influence numerous cell functions.
Purpose of the Study:
- To explore how RNA modifications and structures influence RNA-protein interactions.
- To understand the impact on gene expression processes.
Main Methods:
- Review of emerging evidence on RNA modifications and structures.
- Analysis of RNA-protein interactions in gene expression.
Main Results:
- RNA sequence, folding, and chemical modifications are key regulatory factors.
- The coupling of modifications and structures dictates RNA-protein binding.
- These interactions occur at multiple stages of gene expression.
Conclusions:
- RNA modifications and structures are critical for post-transcriptional regulation.
- Their interplay shapes RNA-protein interactions, controlling gene expression.
- This dynamic regulation is fundamental to cell function.
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