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Gastrin and Gastric Cancer
Helge L Waldum1, Liv Sagatun1, Patricia Mjønes2
1Department of Gastroenterology and Hepatology, St Olav's Hospital, Trondheim, Norway; Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Frontiers in Endocrinology
|February 2, 2017
Summary
Helicobacter pylori (Hp) infection is a primary cause of gastric cancer. Research explores how Hp infection leads to atrophic gastritis and gastric cancer, highlighting gastrin's role.
Area of Science:
- Gastroenterology
- Oncology
- Microbiology
Background:
- Gastric cancer, though less frequent, remains significant due to poor prognosis in Western countries.
- Reduced Helicobacter pylori (Hp) prevalence may explain the decline in gastric cancer incidence.
- Lauren's classification distinguishes intestinal and diffuse gastric carcinoma types with different epidemiology.
Purpose of the Study:
- Investigate the mechanisms by which Hp infection causes gastric cancer.
- Clarify the role of gastrin and enterochromaffin-like cells in gastric carcinogenesis.
- Assess the implications of long-term acid secretion inhibitor use.
Main Methods:
- Review of scientific literature on Hp infection and gastric cancer.
- Analysis of pathological classifications and epidemiological data.
- Examination of the relationship between atrophic gastritis, hypoacidity, and hypergastrinemia.
Main Results:
- Atrophic gastritis of oxyntic mucosa is a key precursor to gastric cancer, potentially via hypoacidity and hypergastrinemia.
- Gastrin and its target enterochromaffin-like cells appear crucial in gastric carcinogenesis.
- Long-term acid secretion inhibition can induce secondary hypergastrinemia.
Conclusions:
- Hp infection is the principal etiological factor for gastric cancer.
- Gastrin plays a significant role in the development of gastric cancer.
- Caution is advised regarding long-term acid suppression therapy due to induced hypergastrinemia.
Keywords:
carcinogenesisclassification of cancergastric cancergastrinhormonesneuroendocrine neoplasiaMore Related Videos
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