Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar
Manjunatha Narayanarao1, Lokesh Koodlur2, Vijayakumar G Revanasiddappa3
1East Point College of Engineering and Technology, VisvesvarayaTechnological University, Aavalahalli, Bangalore-560 049, India.
Abstract:
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis. The method uses the 1,3-dipolar cycloaddition reaction between N-alkylvinylindole/indazole and azomethine ylides, prepared in situ from cyclic/acyclic amino acids. The 1,3-dipolar cycloaddition proceeds efficiently under thermal conditions to afford the regio- and stereospecific cyclic adducts.
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