Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

3.3K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.3K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

1000
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1000
Pulmonary Function Tests01:25

Pulmonary Function Tests

946
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
946
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Lean and Value-Based Healthcare methods to support the chronic heart failure care model.]

Recenti progressi in medicina·2026
Same author

[Value-Based Healthcare analysis of antibiotic administration in non-hospital settings: assessment of patient benefits and economic sustainability of the system.]

Recenti progressi in medicina·2026
Same author

Dupilumab in Severe Asthma-COPD Overlap: Real-Life Experience on a Case Series.

Journal of personalized medicine·2026
Same author

Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study.

Thoracic research and practice·2026
Same author

Real-Life Efficacy of Single-Inhaler Triple Therapy with Budesonide/Glycopyrronium/Formoterol Fumarate in Persistent COPD Users: A Retrospective Database Study.

Biomedicines·2025
Same author

Pre-biologic FeNO might predict anti-IL-5/IL-5Rα response to treatment in severe asthmatics.

The Journal of asthma : official journal of the Association for the Care of Asthma·2025

Related Experiment Video

Updated: Mar 8, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

6.5K

Predicted Values for Spirometry may Underestimate Long-Standing Asthma Severity.

Bruno Sposato1

  • 1Unit of Pneumology, "Misericordia" Hospital, Grosseto, Italy.

The Open Respiratory Medicine Journal
|February 2, 2017
PubMed
Summary

Many long-standing asthmatics (LSA) with normal lung function show significant forced expiratory volume in one second (FEV1) decline over time. This indicates potential underestimation of asthma severity and under-treatment in seemingly well-controlled patients.

Keywords:
AsthmaFEV1 declineLung functionReference valuesSpirometry

More Related Videos

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

8.7K
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

1.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

6.5K
Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

8.7K
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

1.4K

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Medicine

Background:

  • Asthma can lead to accelerated lung function decline, even in patients with normal spirometry readings.
  • Long-standing asthmatics (LSA) may exhibit significant forced expiratory volume in one second (FEV1) decline compared to previous measurements.
  • Assessing FEV1 decline in asymptomatic LSA with normal lung function is crucial for accurate severity assessment.

Purpose of the Study:

  • To evaluate the rate of FEV1 decline in asymptomatic, well-controlled, long-standing asthmatics with normal lung function.
  • To determine the proportion of LSA patients experiencing pathological FEV1 decline based on established criteria.
  • To highlight the importance of longitudinal FEV1 monitoring for accurate asthma management.

Main Methods:

  • Selected 46 well-controlled LSA with normal FEV1 and FEV1/VC using GLI2012 references.
  • Calculated FEV1 decline by comparing the latest measurement to a value at least five years older or the highest predicted value.
  • Defined pathological FEV1 decline as >15% or >30 ml/year.

Main Results:

  • When comparing to a 5-year older FEV1, 28.3% of subjects showed a decline >15%, and 60.8% declined >30 ml/year.
  • Using the highest predicted FEV1 and correcting for physiological decrease, 13% showed FEV1 decline >15%, and 37% declined >30 ml/year.
  • A significant percentage of LSA patients with normal spirometry exhibit pathological FEV1 decline.

Conclusions:

  • FEV1 decline calculation is essential for accurately assessing asthma severity.
  • Standard spirometry may underestimate the severity of asthma in some well-controlled LSA patients.
  • Accurate FEV1 decline assessment can prevent under-treatment of apparent "well-controlled" asthma.