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Updated: Mar 8, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Tuberous Sclerosis in Identical Twins.

Dinesh C Govil, Manju Govil

    Indian Journal of Dermatology, Venereology and Leprology
    |February 2, 2017
    PubMed
    Summary

    Tuberous sclerosis, a genetic disorder, was observed in identical twin brothers. Both presented with characteristic skin lesions and progressive mental deterioration, highlighting the condition's impact.

    Area of Science:

    • Medical Genetics
    • Dermatology
    • Neurology

    Background:

    • Tuberous sclerosis is a rare genetic disorder affecting multiple organs.
    • It is characterized by the formation of benign tumors in various parts of the body.
    • Genetic mutations lead to uncontrolled cell growth.

    Observation:

    • Identical twin brothers, six years old, presented with tuberous sclerosis.
    • Both were born with a single placenta and a single amnion, suggesting potential shared environmental or developmental factors.
    • Clinical manifestations included adenoma sebaceum, shagreen patches, and ash leaf spots.

    Findings:

    • Progressive mental deterioration was noted in both twin brothers.
    • One twin exhibited a verrucous pigmented nevus on the left temple.

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  • Recurrent localized motor seizures were also observed in one of the twins.

    • Implications:

    • This case highlights the variable expressivity of tuberous sclerosis, even in genetically identical individuals.
    • Early recognition of dermatological signs is crucial for timely diagnosis and management.
    • Understanding the genetic and developmental underpinnings can inform future therapeutic strategies.