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Symmetrical Progressive Erythrokeratoderma.

Uma S Agrawal, K Suresh Jain, C M Kuldeep

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    Summary
    This summary is machine-generated.

    A 6-year-old boy presented with symmetrical progressive erythrokeratoderma, a rare skin condition. Unusual involvement of flexural areas alongside typical sites was noted, differentiating it from classical presentations.

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    Area of Science:

    • Dermatology
    • Genetics
    • Pediatrics

    Background:

    • Symmetrical progressive erythrokeratoderma is a rare genodermatosis.
    • Characterized by diffuse, symmetrical, erythematous, and hyperkeratotic plaques.
    • Typically affects palms, soles, and extensor surfaces.

    Observation:

    • A 6-year-old boy presented with asymptomatic, gradually progressive, well-defined, bilateral, erythematohyperkeratotic plaques.
    • Lesions were observed on the dorsa of hands and feet, shins, popliteal fossae, natal cleft, axillae, and anterior abdomen.
    • Palms and soles were notably spared.

    Findings:

    • The clinical presentation was suggestive of symmetrical progressive erythrokeratoderma.
    • The extensive involvement of flexural areas (popliteal fossae, axillae, natal cleft) was an unusual feature.
    • Sparing of palms and soles is atypical for classical forms of erythrokeratoderma.

    Implications:

    • This case highlights the phenotypic variability of symmetrical progressive erythrokeratoderma.
    • The unusual distribution pattern may necessitate a broader differential diagnosis in pediatric dermatology.
    • Further research into genetic and molecular underpinnings is warranted to understand atypical presentations.