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Subcorneal Pustular Dermatosis.

A J Kanwar, Malkit Shigh, Mahdi Ibtesam El-Manghoush

    Indian Journal of Dermatology, Venereology and Leprology
    |February 2, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Two cases of subcorneal pustular dermatosis in children and young adults showed positive results with dapsone treatment. Long-term follow-up confirmed no recurrence after discontinuing dapsone, indicating a potential cure.

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    Area of Science:

    • Dermatology
    • Immunodermatology

    Background:

    • Subcorneal pustular dermatosis (SP D) is a rare inflammatory skin condition.
    • Characterized by sterile pustules located beneath the stratum corneum.

    Observation:

    • Reported are two cases of SP D: a male child and a young female.
    • Both patients presented with characteristic pustular eruptions.

    Findings:

    • Both individuals experienced significant improvement and resolution of symptoms following treatment with dapsone.
    • One patient remained in remission for 1.5 years after dapsone cessation, suggesting sustained efficacy.

    Implications:

    • Dapsone appears to be a highly effective therapeutic option for subcorneal pustular dermatosis.
    • Further research into dapsone's mechanism in SP D could elucidate long-term treatment strategies.