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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
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Serum prealbumin and its changes over time are associated with mortality in acute kidney injury

Wenji Wang1, Yu Pan1, Xiao Tang2

  • 1Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China.

Scientific Reports
|February 2, 2017
PubMed

Insights

Serum prealbumin levels and their changes predict mortality in acute kidney injury (AKI) patients. Monitoring prealbumin can improve 90-day mortality predictions in AKI, offering better prognostic insights.

Area of Science:

  • Nephrology
  • Clinical Nutrition
  • Biomarkers

Background:

  • Serum prealbumin is a key indicator of nutritional status and inflammation.
  • Acute kidney injury (AKI) poses significant mortality risks.
  • Predicting mortality in AKI patients is crucial for timely intervention.

Purpose of the Study:

  • To evaluate if serum prealbumin levels and their weekly changes improve 90-day mortality prediction in AKI patients.
  • To compare the predictive performance of serum prealbumin versus serum albumin for mortality.

Main Methods:

  • Prospective cohort study of 340 adult AKI patients.
  • Analysis of serum prealbumin levels at diagnosis and over one week.
  • Utilized Cox regression models and NRI/aIDI for prediction improvement assessment.

Main Results:

  • Low prealbumin (<10 mg/dL) at AKI diagnosis increased mortality risk (aHR, 2.55).
  • A significant drop in prealbumin (>4 mg/dL) over a week also predicted mortality (aHR, 1.79).
  • Prealbumin and its changes showed superior mortality predictability compared to albumin.

Conclusions:

  • Serum prealbumin levels and their longitudinal changes are independent predictors of poor prognosis in AKI.
  • Incorporating prealbumin metrics enhances the prediction of 90-day mortality in AKI patients.
  • Serum prealbumin serves as a valuable surrogate marker for AKI mortality prediction.

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