Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

7.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale metabolic mapping of lung tissue via coregistered mass spectrometry and nonlinear optical imaging.

Science advances·2026
Same author

Assessment of Noninvasive Measurement Techniques and Histologic Findings in a Mouse Model of LPS-Induced Acute Lung Injury.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026
Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026
Same author

Assessing current capabilities for incorporating lipidomics in multiomics data integration.

Briefings in bioinformatics·2026
Same author

Piecing together the alveolar-capillary unit: arterial-venous capillary polarization.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

AI-Based Digital Pathology-Enabled Spatial-Omics Data Analyses of the Human Kidney.

Journal of proteome research·2026

Related Experiment Video

Updated: Mar 8, 2026

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.8K

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung.

Sydney E Dautel1, Jennifer E Kyle1, Geremy Clair1

  • 1Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.

Scientific Reports
|February 2, 2017
PubMed
Summary
This summary is machine-generated.

This study reveals significant changes in lung lipids during development. Understanding these lipid alterations offers new insights into normal lung growth and potential therapeutic targets for premature infants.

More Related Videos

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
11:26

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung

Published on: July 18, 2016

9.3K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Related Experiment Videos

Last Updated: Mar 8, 2026

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.8K
Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
11:26

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung

Published on: July 18, 2016

9.3K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Area of Science:

  • Pulmonary Science
  • Biochemistry
  • Developmental Biology

Background:

  • Lung immaturity is a critical factor in premature infant mortality.
  • Molecular mechanisms of lung development are key to addressing developmental disruptions.
  • Previous studies focused on transcriptomics and proteomics, leaving the lipidome undercharacterized.

Purpose of the Study:

  • To investigate the murine lung lipidome during postnatal development.
  • To identify specific lipid species and subclasses involved in normal lung growth.
  • To uncover the roles of lipids in processes like apoptosis, inflammation, and energy metabolism during lung development.

Main Methods:

  • Utilized liquid chromatography-mass spectrometry (LC-MS/MS) for comprehensive lipidomics analysis.
  • Analyzed lung tissue from mice at postnatal day 7, day 14, and adulthood (6-8 weeks).
  • Integrated lipidomics data with complementary proteomics, metabolomics, and chemical imaging.

Main Results:

  • Identified 924 unique lipids across 21 subclasses in developing murine lungs.
  • Observed dramatic alterations in the lung lipidome during postnatal development.
  • Revealed insights into sphingolipid roles in apoptosis, inflammation, and energy dynamics.

Conclusions:

  • The study provides a detailed multi-omic view of normal pulmonary development.
  • Characterization of the lung lipidome offers novel insights into developmental processes.
  • Findings may inform strategies to ameliorate disrupted lung development in premature infants.