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Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and
Judith Mayr1, Jürgen Bachl2, Jens Schlossmann3
1Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany. judith.mayr@chemie.uni-regensburg.de.
Abstract:
A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells.
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