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Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
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Published on: October 5, 2015

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[Cytomegalovirus disease in post-heart-transplant patients at a national reference center]

Christian Rojas-Contreras1, Gabriel De la Cruz-Ku2, Bryan Valcarcel-Valdivia2

  • 1Servicio de Infectología, Instituto Nacional Cardiovascular, Lima, Perú.

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|February 2, 2017
PubMed

Insights

Cytomegalovirus disease affects 5.7% of heart transplant recipients, often occurring despite prophylaxis. Prompt diagnosis and treatment are crucial for remission in these patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Heart transplantation is the primary treatment for end-stage heart failure.
  • Cytomegalovirus (CMV) disease is a significant post-transplant infectious complication.

Purpose of the Study:

  • To determine the prevalence of cytomegalovirus disease post-heart transplant.
  • To describe the clinical features of cytomegalovirus disease in heart transplant recipients.

Main Methods:

  • Retrospective descriptive study of 35 heart transplant patients (2010-2015).
  • Data collected via medical record review.
  • Analysis of demographic and clinical variables for CMV disease cases.

Main Results:

  • Prevalence of cytomegalovirus disease was 5.7% (2 patients).
  • Both affected patients were cytomegalovirus-seronegative pre-transplant.
  • CMV disease occurred both during and after valganciclovir prophylaxis.

Conclusions:

  • The prevalence of CMV disease in this cohort is lower than reported in other studies.
  • Cytomegalovirus disease can be successfully treated with timely diagnosis and appropriate medical management.
Abstract

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