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Updated: Mar 8, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
[Infective endocarditis by Abiotrophia defectiva diagnosed by mass spectrometry (MALDI-TOF MS) in Argentina]
Flavo Lipari1, Matías Martínez2, Daniela Hernández3
1Servicio de Infectología, Hospital Privado Universitario de Córdoba, Argentina.
Abstract:
We report the case of a 63-year-old woman with congestive heart failure due to a bicuspid aortic valve and severe aortic stenosis. The patient had a febrile syndrome with positive blood cultures for Abiotrophia defectiva, Transesophageal echocardiogram revealed the presence of paravalvular abscess, which was treated by a successful valve replacement. The patient received appropriate antibiotic therapy with intravenous vancomycin, leading to a successful response. The use of MALDI-TOF MS as a rapid and specific method for the microbiological diagnosis is discussed in the following report.
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