Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Combined optical-electromechanical wearable sensors for cardiac health monitoring.

Journal of biomedical optics·2025

Same author

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend.

ACS sensors·2024

Same author

Dynamic Response Study of Piezoresistive Ti<sub>3</sub>C<sub>2</sub>-MXene Sensor for Structural Impacts.

Sensors (Basel, Switzerland)·2023

Same author

Material jetting of carbon nano onions for printed electronics.

Nanotechnology·2023

Same author

Suitability of nanoparticles for gamma-ray applications.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2022

Same author

Design of Arbitrary Magnetic Patterns on Magnetic Polymer Composite Objects: A Finite Element Modelling Tool.

Polymers·2022

Search research articles

Related Experiment Video

Updated: Mar 8, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Packaged peristaltic micropump for controlled drug delivery application.

K B Vinayakumar¹, Girish Nadiger², Vikas R Shetty²

¹Department of Instrumentation and Applied Physics, Indian Institute Of Science, Bangalore 560012, India.

The Review of Scientific Instruments

|February 3, 2017

Summary

This study developed a DC-motor driven peristaltic micropump for precise drug delivery. The system offers controlled micro-liter to milli-liter fluid delivery with high accuracy and a fail-safe mechanism.

More Related Videos

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

Related Experiment Videos

Last Updated: Mar 8, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

Area of Science:

Biomedical Engineering
Microfluidics
Drug Delivery Systems

Background:

Micropump technology is crucial for micro Total Analysis Systems (μTAS) and drug delivery.
Current micropumps face limitations in control, handling, and flow rate accuracy.
Peristaltic pumps offer potential for precise fluid handling in microfluidic applications.

Purpose of the Study:

To design, develop, and characterize a DC-motor driven peristaltic micropump.
To achieve precision flow control for controlled drug delivery applications.
To integrate the micropump with electronics and develop an Android application for insulin self-administration.

Main Methods:

Fabrication of micropump components using conventional techniques.
Characterization of volume flow variation with different viscous fluids and back pressures.
Testing of fail-safe operation and measurement of leak rate.
Achieving precision flow control by monitoring pinch cam position and load current.

Main Results:

The micropump demonstrated controlled delivery from microliter to milliliter volumes.
Leak rate was measured at approximately 0.14% for an inlet pressure of 140 kPa.
Precision flow control was achieved and validated after 300 rotations.
A complete system with an Android application for insulin delivery was successfully integrated.

Conclusions:

The developed DC-motor driven peristaltic micropump is suitable for controlled drug delivery.
The system offers high accuracy, precision, and a fail-safe mechanism.
The integrated system and Android application enable self-administration of insulin, advancing personalized medicine.