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Published on: February 8, 2022
Early Correction of Common Atrioventricular Septal Defects: A Single-Center 20-Year Experience
Vladimiro L Vida1, Chiara Tessari1, Biagio Castaldi2
1Paediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Insights
Early surgical repair of common atrioventricular canal defects (CAVCD) is safe and effective. This study shows good early and long-term outcomes for patients undergoing CAVCD repair, emphasizing individualized early intervention.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Surgery
- Cardiovascular Research
Background:
- Established policy of elective repair for common atrioventricular canal defects (CAVCD) in infants aged 8-12 weeks.
- Long-term evaluation of a 20-year surgical experience with CAVCD repair.
Purpose of the Study:
- To assess the outcomes of a 20-year policy of elective CAVCD repair in infants.
- To identify factors influencing reoperation and long-term valve performance.
Main Methods:
- Retrospective review of 159 consecutive patients undergoing CAVCD repair (January 1992 - April 2014).
- Surgical techniques included double-patch (86%) and modified single-patch (14%).
- Analysis of operative mortality, late mortality, reoperation rates, and left atrioventricular valve (LAVV) performance.
Main Results:
- 3 operative (1.9%) and 12 late (7.7%) deaths occurred.
- 13% of patients required reoperation, primarily for LAVV regurgitation (10%).
- LAVV dysplasia and cleft closure were associated with increased reoperation risk; older age at repair (>3 months) and LAVV dysplasia worsened late LAVV performance.
Conclusions:
- Individualized early repair of CAVCD is a safe and beneficial strategy.
- The study demonstrates good early and long-term results supporting this approach.
- Attention to LAVV status and timing of repair is crucial for optimal outcomes.
Background:
Over the past 20 years our policy has been to electively repair common atrioventricular canal defects (CAVCD) in patients between 8 and 12 weeks of age. We sought to evaluate the results of our past 20-year experience.
Methods:
From January 1992 to April 2014, 159 consecutive patients underwent CAVCD repair (133 patients had complete CAVCD and 26 patients had a transitional form of CAVCD).
Results:
Surgical repair was accomplished with a double-patch (n = 137 [86%]) or a modified single patch (n = 22 [14%]) technique. Median age at operation was 96 days (interquartile range [IQR], 73-128 days); 90 patients were younger than 3 months of age. There were 3 operative (1.9%) and 12 late (7.7%) deaths. Median follow-up time after repair was 8.2 years (IQR, 3.6-15 years). Twenty patients (13%) required reoperation-16 (10%) for left atrioventricular valve (LAVV) regurgitation. Reoperation on the LAVV was more frequent in patients with a dysplastic LAVV preoperatively (p = 0.01; odds ratio [OR], 4.2; 95% confidence interval [CI], 1.33-13.5) and in patients who underwent closure for an absent/incomplete cleft at the time of repair (p = 0.01; OR, 5.4; 95% CI, 1.4-21). Late LAVV performance (regurgitation greater than or equal to moderate or the need for reoperation), including late deaths and patients who underwent reoperation, was significantly worse in patients older than 3 months at repair (10 of 83 patients [12%] versus 20 of 73 patients [27%]; hazard ratio [HR], 2.71; 95% CI, 1.19-6.19) and in patients with LAVV dysplasia (19 of 68 patients [28%] versus 11 of 88 patients [12%]; HR, 3; 95% CI, 1.53-8.51).
Conclusions:
Individualized early repair of CAVCD is safe and beneficial, with good early and long-term results.
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