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Published on: February 26, 2019

LMO4 is a prognostic marker involved in cell migration and invasion in non-small-cell lung cancer

Wenjun Wang¹, Sipei Wu², Minzhang Guo¹

¹State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Journal of Thoracic Disease

|February 3, 2017

Abstract

Background:

The aims of this study were to analyze the association of LMO4 with non-small-cell lung cancer (NSCLC) survival rate, and to determine its functional role and signaling pathway in lung cancer.

Methods:

Immunohistochemistry (IHC) was used to detect the expression of LMO4 in NSCLC cell lines and tumor tissues. Migration and invasion ability was detected respectively by wound healing test and transwell test. Immunofluorescence and western blot were detected of AKT/PI3K pathway related genes MAPK, PI3K, AKT.

Results:

LMO4 has high expression level of NSCLC cell lines and tumor tissues, and correlated with a lower survival rate. LMO4 can regulate the migration and invasion of NSCLC cells through the AKT/PI3K pathway.

Conclusions:

LMO4 could serve as a promising biomarker and therapeutic target for NSCLC.

Keywords:

LMO4 invasion migration non-small-cell lung cancer (NSCLC)

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