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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Related Experiment Video

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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Acne and Rosacea.

Mauro Picardo1, Lawrence F Eichenfield2, Jerry Tan3

  • 1San Gallicano Dermatologic Institute, Rome, Italy. mauro.picardo@ifo.gov.it.

Dermatology and Therapy
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Summary
This summary is machine-generated.

Acne and rosacea are common skin conditions with complex causes. Recent research advances understanding of their pathogenesis and epidemiology, paving the way for improved treatments.

Keywords:
AcneAcne vulgarisAdolescentPathogenesisPediatricPre-adolescentRosaceaTherapy

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Area of Science:

  • Dermatology and skin science research.

Background:

  • Acne affects 85% of adolescents, linked to sebum, keratinocytes, inflammation, and bacteria.
  • Rosacea is a chronic facial inflammatory condition involving vasoactive and neurocutaneous mechanisms.
  • Both acne and rosacea have multifactorial pathologies that are not fully understood.

Purpose of the Study:

  • To provide an overview of current perspectives on acne and rosacea pathogenesis and treatment.
  • To summarize recent pathophysiology findings with implications for clinical practice.

Main Methods:

  • Review of current scientific literature and recent landmark studies.
  • Synthesis of information on pathogenesis, epidemiology, and therapeutic interventions.

Main Results:

  • Advances in understanding acne mechanisms including Propionibacterium acnes.
  • Progress in elucidating rosacea's complex vasoactive and neurocutaneous pathways.
  • Identification of new therapeutic interventions for both conditions.

Conclusions:

  • Enhanced knowledge of acne and rosacea pathways will drive therapeutic pipeline advancements.
  • Future research promises a wider array of treatments to address current management gaps.