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Updated: Mar 8, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
CATH-Gene3D: Generation of the Resource and Its Use in Obtaining Structural and Functional Annotations for Protein
Natalie L Dawson1, Ian Sillitoe2, Jonathan G Lees2
1Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK. natalie.dawson.09@ucl.ac.uk.
Abstract:
This chapter describes the generation of the data in the CATH-Gene3D online resource and how it can be used to study protein domains and their evolutionary relationships. Methods will be presented for: comparing protein structures, recognizing homologs, predicting domain structures within protein sequences, and subclassifying superfamilies into functionally pure families, together with a guide on using the webpages.
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