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Updated: Mar 8, 2026

Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange ABE
Published on: February 18, 2013
Roles of palmitoylation in axon growth, degeneration and regeneration
Sabrina M Holland1, Gareth M Thomas1,2
1Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair).
Abstract:
The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease. © 2017 Wiley Periodicals, Inc.
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