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Reference intervals for growth arrest-specific 6 protein in adults
Zeynep Cagman1, Ozlem Bingol Ozakpinar1, Zeynep Cirakli2
1a Marmara University School of Pharmacy , Department of Biochemistry , Istanbul , Turkey.
Scandinavian Journal of Clinical and Laboratory Investigation
|February 3, 2017
Summary
This study establishes reference intervals for plasma growth arrest-specific 6 (GAS6) in healthy adults, providing crucial clinical laboratory standards. The findings offer a reliable range for GAS6 levels, aiding in disease diagnosis and monitoring.
Area of Science:
- Clinical Biochemistry
- Laboratory Medicine
- Protein Analysis
Background:
- Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein with implications in various physiological and pathological processes.
- Establishing reliable reference intervals for GAS6 is essential for its accurate clinical interpretation.
Purpose of the Study:
- To determine the reference intervals for human adult plasma GAS6.
- To adhere to the Clinical and Laboratory Standards Institute (CLSI) C28-A3 guideline for establishing these intervals.
Main Methods:
- Collected blood samples from 308 healthy adult volunteers (157 female, 151 male) aged 18-72.
- Utilized a non-parametric approach to calculate the reference interval for plasma GAS6.
- Analyzed data for potential partitioning by age and gender using Harris-Boyd's test.
Main Results:
- The plasma GAS6 reference interval was established as 2.5-18.8 μg/L (90% CI).
- No significant partitioning by age or gender was observed.
- Intra-assay and inter-assay variations were 12.6% and 14.0%, respectively, with a mean recovery of 104%.
Conclusions:
- This study provides the first plasma GAS6 reference intervals established following the CLSI C28-A3 guideline.
- The determined reference intervals offer a standardized benchmark for clinical assessment of GAS6 levels.
