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Updated: Mar 8, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Methotrexate Therapy For Psoriasis(A Preliminary Report)
Indian Journal of Dermatology, Venereology and Leprology
|February 3, 2017
Summary
Methotrexate effectively treated chronic severe psoriasis in all 14 patients resistant to other therapies. This study highlights methotrexate
Area of Science:
- Dermatology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Severe psoriasis often proves resistant to conventional treatments.
- Psoriatic erythroderma and extensive disease represent severe forms.
Purpose of the Study:
- To evaluate the efficacy of methotrexate in patients with chronic severe intractable psoriasis.
- To assess methotrexate's effectiveness in cases resistant to standard therapies.
Main Methods:
- Oral administration of methotrexate in single weekly doses.
- Dosage ranged from 20-30 mg per week.
- Study included 14 patients (9 males, 5 females) with severe psoriasis.
Main Results:
- Methotrexate therapy was effective in all 14 patients.
- All patients with psoriatic erythroderma and extensive disease showed improvement.
- Observed side effects included nausea, vomiting, headache, abdominal pain, alopecia, and appetite loss.
Conclusions:
- Methotrexate is an effective treatment for chronic severe intractable psoriasis.
- It offers a viable therapeutic option for patients refractory to conventional treatments.
- Monitoring for side effects is important during methotrexate therapy.
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