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Report of Three Cases Having Primary Dapsone Resistance in Paucibacillary Leprosy

P A Sarojini, O Raveendranathan, B K Hareendran Nair

    Indian Journal of Dermatology, Venereology and Leprology
    |February 3, 2017
    PubMed

    Insights

    Primary dapsone resistance in leprosy is a growing concern. Combined therapy with rifampicin and clofazimine effectively treated patients who deteriorated on dapsone monotherapy.

    Area of Science:

    • Dermatology
    • Infectious Diseases
    • Microbiology

    Background:

    • Leprosy, a chronic infectious disease, is primarily treated with dapsone monotherapy for paucibacillary forms.
    • Primary dapsone resistance can lead to treatment failure and disease progression.
    • Monitoring treatment response is crucial for managing leprosy.

    Observation:

    • Three cases of indeterminate leprosy presented with deterioration despite supervised dapsone monotherapy.
    • These patients had not previously received leprosy treatment, indicating primary resistance.

    Findings:

    • All three cases exhibited primary dapsone resistance.
    • Successful treatment outcomes were achieved with a combination regimen of rifampicin and clofazimine.
    • This suggests the efficacy of multidrug therapy in cases of dapsone resistance.

    Implications:

    • Highlights the need for vigilance regarding dapsone resistance in leprosy management.
    • Supports the use of multidrug therapy as a primary treatment strategy in endemic areas.
    • Underscores the importance of early detection and alternative treatment regimens for resistant leprosy cases.

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