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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Histopathological Study of Diffuse Idiopathic Melanoderma.

N G Jogaikar, Mohan B Gharpuray, Vinay Kulkarni

Indian Journal of Dermatology, Venereology and Leprology

|February 3, 2017

Summary

This summary is machine-generated.

Diffuse idiopathic melanoderma involves increased basal cell melanin and inflammation. Histopathology shows distinct features differentiating it from lichen planus, aiding diagnosis.

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Area of Science:

Dermatopathology
Histology

Background:

Diffuse idiopathic melanoderma is a skin condition characterized by changes in pigmentation.
Understanding its histopathological features is crucial for accurate diagnosis.

Purpose of the Study:

To conduct a histopathological examination of skin samples from patients with diffuse idiopathic melanoderma.
To compare the histopathological findings with clinical presentation and differentiate from other conditions like lichen planus.

Main Methods:

Histopathological analysis of 30 cases of diffuse idiopathic melanoderma, examining both affected and normal skin.
Evaluation of key features including melanin pigmentation, basal cell changes, epidermal alterations, and inflammatory infiltrate.

Main Results:

All cases showed increased basal layer melanin pigmentation.
Liquefactive degeneration of basal cells (20 cases), epidermal atrophy (17 cases), and melanophages (26 cases) were observed.
A perivascular or diffuse lympho-histiocytic infiltrate was present in 28 cases.
Distinct histopathological differences from lichen planus were noted.

Conclusions:

Histopathology of diffuse idiopathic melanoderma reveals characteristic features such as hyperpigmentation and inflammation.
These findings help distinguish it from lichen planus, improving diagnostic accuracy.