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Ketoconazole Therapy in Pityriasis Versicolor.

M Shafi, M L Khatri

    Indian Journal of Dermatology, Venereology and Leprology
    |February 3, 2017
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    Summary

    A 14-day course of oral ketoconazole demonstrated a higher cure rate for pityriasis versicolor compared to a 10-day regimen. This antifungal treatment showed minimal side effects, with only one patient experiencing nausea.

    Area of Science:

    • Dermatology
    • Mycology
    • Pharmacology

    Background:

    • Pityriasis versicolor is a common superficial fungal infection.
    • Ketoconazole is an imidazole antifungal agent used to treat fungal infections.

    Purpose of the Study:

    • To compare the efficacy of 10-day versus 14-day oral ketoconazole courses for treating pityriasis versicolor.
    • To assess the safety and recurrence rates associated with these treatment durations.

    Main Methods:

    • Twenty-six patients diagnosed with pityriasis versicolor were enrolled.
    • Treatment involved oral ketoconazole administered for either 10 or 14 consecutive days.

    Main Results:

    • The 14-day ketoconazole schedule achieved a higher cure rate than the 10-day schedule.

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  • One patient experienced recurrence of the infection.
  • Adverse effects were minimal, with only one case of significant nausea reported.

    • Conclusions:

    • A 14-day course of oral ketoconazole is more effective for pityriasis versicolor than a 10-day course.
    • Oral ketoconazole is generally well-tolerated for this indication.
    • Longer treatment duration may improve outcomes and reduce recurrence.