Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Papillary Dermis01:11

Papillary Dermis

6.5K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.5K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.2K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K
Pigmentation01:19

Pigmentation

4.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.8K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
Cells of the Epidermis01:24

Cells of the Epidermis

8.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eosinophilic Meningitis: A Live Evidence.

Indian pediatrics·2025
Same author

Xanthoma Disseminatum.

Indian journal of dermatology, venereology and leprology·2017
Same author

Orificial Tuberculosis.

Indian journal of dermatology, venereology and leprology·2017
Same author

Primary Inoculation Tuberculosis.

Indian journal of dermatology, venereology and leprology·2017
Same author

Contact Dermatitis in Trivandrum.

Indian journal of dermatology, venereology and leprology·2017
Same author

Early diagnosis of post-varicella necrotising fasciitis: A medical and surgical emergency.

African journal of paediatric surgery : AJPS·2016
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.9K

Epidermal Nevus Syndrome.

S M Shanmugham Pillai, Vinod Jacob Cherian

    Indian Journal of Dermatology, Venereology and Leprology
    |February 3, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Epidermal nevus syndrome is a rare condition affecting a seven-year-old boy with developmental delays, microcephaly, short stature, and neurological issues. The case highlights the syndrome's diverse systemic manifestations, including ocular palsies and a bone cyst.

    More Related Videos

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
    05:39

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

    Published on: May 16, 2025

    784
    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
    06:34

    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

    Published on: August 8, 2025

    636

    Related Experiment Videos

    Last Updated: Mar 8, 2026

    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
    06:15

    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

    Published on: August 9, 2024

    1.9K
    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
    05:39

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

    Published on: May 16, 2025

    784
    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
    06:34

    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

    Published on: August 8, 2025

    636

    Area of Science:

    • Dermatology
    • Pediatrics
    • Neurology

    Background:

    • Epidermal nevus syndrome (ENS) is a rare congenital disorder characterized by the abnormal development of ectodermal and mesodermal tissues.
    • It presents with a wide spectrum of clinical manifestations, affecting multiple organ systems.

    Observation:

    • A seven-year-old male child presented with a complex phenotype suggestive of epidermal nevus syndrome.
    • Clinical features included delayed milestones, microcephaly, short stature, and central nervous system abnormalities.
    • Specific neurological findings encompassed ocular palsies and nystagmus.

    Findings:

    • The patient exhibited a significant cutaneous manifestation, specifically nevus unius lateris.
    • Radiographic examination revealed a bone cyst in the lower end of the right femur.
    • The combination of neurological, skeletal, and dermatological findings confirmed the diagnosis of epidermal nevus syndrome.

    Implications:

    • This case underscores the importance of a multidisciplinary approach in diagnosing and managing epidermal nevus syndrome due to its multisystemic involvement.
    • Early recognition and comprehensive evaluation are crucial for addressing developmental challenges and potential complications.
    • Further research into the genetic underpinnings and long-term outcomes of ENS is warranted.