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Related Experiment Video

Updated: Mar 8, 2026

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Soybean-fragmented proteoglycans against skin aging.

Clara Barba1, Cristina Alonso1, Isabel Sánchez2

  • 1a Department of Chemical and Surfactants Technology , Instituto de Química Avanzada de Cataluña , Barcelona , Spain.

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
|February 3, 2017
PubMed
Summary

This study shows Proteum serum, containing soybean-fragmented proteoglycans, effectively combats skin aging by boosting collagen and proteoglycan production. It improves skin roughness and barrier function, offering protection against oxidative stress.

Keywords:
Antioxidantproteoglycansskin barrierskin physiologyskin structure

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Biochemistry

Background:

  • Age-dependent skin aging primarily affects the dermis, altering collagen and proteoglycan levels.
  • Extracellular matrix degradation contributes significantly to visible signs of skin aging.

Purpose of the Study:

  • To evaluate the efficacy of Proteum serum, a novel formulation with soybean-fragmented proteoglycans, in mitigating skin aging.
  • To investigate the serum's impact on collagen and proteoglycan synthesis and its protective effects on skin.

Main Methods:

  • In vitro assays assessed Proteum serum's capacity to stimulate collagen and proteoglycan production.
  • In vivo studies evaluated long-term skin application, including protection against detergent-induced dermatitis and antioxidant properties.

Main Results:

  • In vitro tests confirmed the serum's ability to enhance the production of key dermal extracellular matrix components.
  • In vivo measurements indicated a positive trend in improving skin parameters following serum application.

Conclusions:

  • Proteum serum demonstrated a beneficial effect, improving skin roughness and reinforcing the skin barrier.
  • The serum exhibited significant protective action against lipid peroxides (LPO) in the human stratum corneum.