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Reference intervals for common biochemistry laboratory tests in the Saudi population by a direct a priori method
Xuejiao L Hu, Huda Hassan1, Fouad Hassan Al-Dayel1
1Dr. Fouad Hassan Al-Dayel, King Faisal Specialist Hospital and Research Center,, Pathology & Laboratory Medicine,, Riyadh, 11211, Saudi Arabia, T: 966-11-442-7224, F: 966-11-442-4280, dayelf@kfshrc.edu.sa.
Background:
Reference intervals (RI) for biochemistry laboratory tests are now based on Caucasian rather than Saudi populations. Test parameters may vary because of race, lifestyle, population structure and geographic location.
Objectives:
To establish reference intervals for common clinical chemistry laboratory tests for the Saudi population.
Design:
Direct a priori method.
Setting:
Tertiary care hospital.
Materials And Methods:
Blood samples were taken from 625 individuals aged from 2 to 87 years from different geographic areas for 93 biochemistry tests. RIs were established following the International Federation of Clinical Chemistry guideline.
Main Outcome Measure(S):
Reference values for common biochemistry lab tests.
Results:
Ninety-three age- or gender-stratified reference intervals (RIs) based on the Saudi population were established. There were 72 non-partitioned tests. Most of the tests were similar to RIs from manufacturer's inserts. For some sex hormones (estrogen, luteinizing hormone, follicle-stimulating hormone, progesterone and 17 alpha-Hydroxyprogesterone) only male RIs were established as there were not enough samples to stratify for females based on physiologic status.
Conclusion:
The RIs are reliable and applicable to a general Saudi population.
Limitations:
Due to the sample size, RIs were not generated for some sex hormones for females.
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