Related Experiment Video
Updated: Mar 8, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Solvent-Responsive Molecularly Imprinted Nanogels for Targeted Protein Analysis in MALDI-TOF Mass Spectrometry
Maddalena Bertolla1, Lucia Cenci2, Andrea Anesi1
1Department of Physics, University of Trento , Via Sommarive 14, 38123 Trento, Italy.
Abstract:
Molecular imprinted poly(acrylamido)-derivative nanogels have shown their selectivity to bind the protein human serum transferrin (HTR) and also showed their capability for instantaneous solvent-induced modification upon the addition of acetonitrile. Integrated to matrix-assisted laser desorption/ionization time-of-flight mass analysis the HTR-imprinted solvent-responsive nanogels permitted the determination of HTR straight from serum and offered novel perspectives in targeted protein analysis.
Related Concept Videos
MALDI-TOF Mass Spectrometry
Matrix-Assisted Laser Desorption Ionization (MALDI)

