Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

73.1K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
73.1K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

1.4K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
1.4K
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

66
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
66

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Expert Consensus on the Diagnosis and Clinical Management of Primary Fetal Pleural Effusion.

Prenatal diagnosis·2026
Same author

Natural History of Fetal Non-Nuchal Lymphatic Malformations: A Single Center Retrospective Study.

Prenatal diagnosis·2026
Same author

Fetal Brain Abnormalities Following Laser Surgery for Twin-to-Twin Transfusion Syndrome: Imaging Patterns and Evolution.

Prenatal diagnosis·2026
Same author

Prenatal and Perinatal Outcomes in Fetuses With Macrocystic Congenital Pulmonary Airway Malformations: Thoracoamniotic Shunting Versus Expectant Management.

Prenatal diagnosis·2026
Same author

Neuroimaging Findings and Risk Factors for Brain Injury in Foetuses Treated for Anaemia.

Prenatal diagnosis·2026
Same author

Enhancing fetal spina bifida repair: do paraspinal myofascial flaps and acellular dermal patches improve postnatal outcomes? A retrospective cohort review.

Journal of neurosurgery. Pediatrics·2026

Related Experiment Video

Updated: Mar 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

18.1K

Maternal risks of fetal therapy.

Alyaa Al-Refai1, Greg Ryan, Tim Van Mieghem

  • 1Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Current Opinion in Obstetrics & Gynecology
|February 3, 2017
PubMed
Summary

Prenatal therapy for fetal disorders is increasingly available. While medical treatments have rare severe maternal risks, surgical interventions carry higher risks, necessitating informed patient counseling.

Area of Science:

  • Maternal-Fetal Medicine
  • Fetal Surgery
  • Prenatal Diagnosis and Treatment

Background:

  • Most fetal disorders are managed postnatally.
  • Certain conditions necessitate prenatal intervention due to high fetal/neonatal mortality or significant in-utero progression.
  • The global availability of fetal therapeutic procedures is expanding.

Purpose of the Study:

  • To inform patients and caregivers about the potential maternal risks associated with prenatal therapeutic interventions.
  • To provide a foundation for counseling expectant mothers regarding the risks of fetal therapy.

Main Methods:

  • Review of maternal risks associated with transplacental medical therapy.
  • Assessment of maternal complication rates for minimally invasive fetal procedures.

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.4K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.2K

Related Experiment Videos

Last Updated: Mar 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

18.1K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.4K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.2K
  • Evaluation of maternal risks linked to open fetal surgery in current and subsequent pregnancies.

    • Main Results:

    • Transplacental medical therapy (e.g., corticosteroids, antiarrhythmics, immunoglobulins) rarely causes severe maternal adverse events in expert centers.
    • Minimally invasive procedures have approximately 5% maternal complication risk, with 1% severe outcomes (e.g., pulmonary edema, placental abruption).
    • Open fetal surgery presents significant maternal risks, including pulmonary edema, placental abruption, chorioamnionitis, scar dehiscence, and uterine rupture in future pregnancies, though risks are decreasing with advancements.

    Conclusions:

    • Counseling expectant mothers on the risks of fetal therapy is crucial.
    • Understanding maternal risks is essential for informed decision-making regarding prenatal interventions.
    • Ongoing refinement in surgical techniques and team experience is mitigating some risks of open fetal surgery.